Supplement monograph
St. John's Wort
A mood-positioned botanical where antidepressants, oral contraceptives, transplant drugs, anticoagulants, and photosensitivity make interaction screening non-negotiable.
Practical read
Do not place St. John's Wort in a stack until medication context is reviewed. It can change exposure to multiple medicines, so the first timing question is whether it belongs in the plan at all.
Decision frame
St. John's Wort: what to check before it earns a slot
Timing rule
Do not place St. John's Wort in a stack until medication context is reviewed. It can change exposure to multiple medicines, so the first timing question is whether it belongs in the plan at all.
Form lens
Safety lens
Best fit
- High-risk interaction audits
- Mood-stack safety review
- Medication-context education
Form notes
- Standardized extract: common supplement format
- Mood blends: hardest to audit
- Tea or tincture formats: variable exposure
Watchouts
- Can interact with antidepressants and raise serotonin-syndrome concerns
- Can reduce effectiveness of some medicines including oral contraceptives
- Photosensitivity and surgery contexts deserve review
Sources and next checks
Evidence Brief
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These statements have not been evaluated by the FDA. Not intended to diagnose, treat, cure, or prevent any disease. Generated by AI. Always verify with a healthcare professional. Educational information only. Not a substitute for professional medical advice.