Interaction guide

St. John's Wort and antidepressant context

St. John's Wort can interact with antidepressants and many other medicines, so it belongs in a medication-safety review before any mood-stack experiment.

Default spacing rule

If antidepressants, oral contraceptives, transplant drugs, anticoagulants, HIV medicines, or other high-stakes prescriptions are in the picture, treat St. John's Wort as a clinician-and-pharmacist review item before adding or changing it.

Interaction map

St. John's Wort and antidepressant context: the decision path

Check these

St. John's Wort extractsMood-support blendsSSRIs and SNRIsOral contraceptivesTransplant and anticoagulant medicines

Default action

If antidepressants, oral contraceptives, transplant drugs, anticoagulants, HIV medicines, or other high-stakes prescriptions are in the picture, treat St. John's Wort as a clinician-and-pharmacist review item before adding or changing it.

Why it matters

Serotonin-syndrome concern with serotonergic medicinesReduced effectiveness of some medicationsHidden exposure in mood or sleep blends

Products to check

  • St. John's Wort extracts
  • Mood-support blends
  • SSRIs and SNRIs
  • Oral contraceptives
  • Transplant and anticoagulant medicines

Why it matters

  • Serotonin-syndrome concern with serotonergic medicines
  • Reduced effectiveness of some medications
  • Hidden exposure in mood or sleep blends

Sources and related pages

NCCIH St. John's Wort overviewMedlinePlus St. John's Wort precautionsSt. John's Wort monographSafety review standardsInteraction checker

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These statements have not been evaluated by the FDA. Not intended to diagnose, treat, cure, or prevent any disease. Generated by AI. Always verify with a healthcare professional. Educational information only. Not a substitute for professional medical advice.